Appetite, I Hardly Know Her (Pt. 2)

A brief mind-map of the etiology of the anorexia of aging. Figure was altered from its original format found in reference #9
Ghrelin and leptin serve as the main controllers of the orexigenic and anorectic pathways respectively. The orexigenic pathway in the ARC (AgRP neurons) are stimulated by ghrelin. The anorectic pathway in the ARC (POMC neurons) are stimulated by leptin. Activation of the anorectic pathway suppresses appetite, whereas, activation of the orexigenic pathway de-supresses appetite through second-order neurons. This figure is from reference #9
CNA= Certified Nursing Assistant (depending on the floor of the nursing home, the day of the week, and the meal, the number of CNA’s per meal varied widely, and it definitely was evident in the food intake of the residents).
  1. Mattes, R., Hollis, J., Hayes, D., & Stunkard, A. (2005). Appetite: Measurement and Manipulation Misgivings. Journal Of The American Dietetic Association, 105(5), 87–97. doi: 10.1016/j.jada.2005.02.029
  2. Berthoud, H. (2004). Mind versus metabolism in the control of food intake and energy balance. Physiology & Behavior, 81(5), 781–793. doi: 10.1016/j.physbeh.2004.04.034
  3. Corwin, R., & Hajnal, A. (2005). Too much of a good thing: Neurobiology of non-homeostatic eating and drug abuse. Physiology & Behavior, 86(1–2), 5–8. doi: 10.1016/j.physbeh.2005.06.021\
  4. Cameron, J., & Doucet, É. (2007). Getting to the bottom of feeding behaviour: who’s on top?. Applied Physiology, Nutrition, And Metabolism, 32(2), 177–189. doi: 10.1139/h06–072
  5. Leibowitz, S. (2007). Overconsumption of dietary fat and alcohol: Mechanisms involving lipids and hypothalamic peptides. Physiology & Behavior, 91(5), 513–521. doi: 10.1016/j.physbeh.2007.03.018
  6. Saper, C., Chou, T., & Elmquist, J. (2002). The Need to Feed. Neuron, 36(2), 199–211. doi: 10.1016/s0896–6273(02)00969–8
  7. Zigman, J., & Elmquist, J. (2003). Minireview: From Anorexia to Obesity — The Yin and Yang of Body Weight Control. Endocrinology, 144(9), 3749–3756. doi: 10.1210/en.2003–0241
  8. Elmquist, J., Maratos-Flier, E., Saper, C., & Flier, J. (1998). Unraveling the central nervous system pathways underlying responses to leptin. Nature Neuroscience, 1(6), 445–450. doi: 10.1038/2164
  9. Renesselear (2019). Appetite Regulation (Endocrinology ) Flashcards. Retrieved 6 January 2020, from https://www.memorangapp.com/flashcards/41886/Appetite+Regulation/
  10. Hays, N., & Roberts, S. (2006). The anorexia of aging in humans. Physiology & Behavior, 88(3), 257–266. doi: 10.1016/j.physbeh.2006.05.029
  11. Schiffman, S. (1997). Taste and Smell Losses in Normal Aging and Disease. JAMA: The Journal Of The American Medical Association, 278(16), 1357. doi: 10.1001/jama.1997.03550160077042
  12. Schiffman, S. (2018). Influence of medications on taste and smell. World Journal Of Otorhinolaryngology — Head And Neck Surgery, 4(1), 84–91. doi: 10.1016/j.wjorl.2018.02.005
  13. Dwyer, L., Han, B., Woodwell, D., & Rechtsteiner, E. (2010). Polypharmacy in nursing home residents in the United States: Results of the 2004 National Nursing Home Survey. The American Journal Of Geriatric Pharmacotherapy, 8(1), 63–72. doi: 10.1016/j.amjopharm.2010.01.001
  14. Rolls, B., Dimeo, K., & Shide, D. (1995). Age-related impairments in the regulation of food intake. The American Journal Of Clinical Nutrition, 62(5), 923–931. doi: 10.1093/ajcn/62.5.923
  15. Clarkston, W., Pantano, M., Morley, J., Horowitz, M., Littlefield, J., & Burton, F. (1997). Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. American Journal Of Physiology-Regulatory, Integrative And Comparative Physiology, 272(1), R243-R248. doi: 10.1152/ajpregu.1997.272.1.r243
  16. Moriguti, J., Das, S., Saltzman, E., Corrales, A., McCrory, M., Greenberg, A., & Roberts, S. (2000). Effects of a 6-Week Hypocaloric Diet on Changes in Body Composition, Hunger, and Subsequent Weight Regain in Healthy Young and Older Adults. The Journals Of Gerontology Series A: Biological Sciences And Medical Sciences, 55(12), B580-B587. doi: 10.1093/gerona/55.12.b580
  17. Rigamonti, A., Pincelli, A., Corra, B., Viarengo, R., Bonomo, S., & Galimberti, D. et al. (2002). Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. Journal Of Endocrinology, 175(1), R1-R5. doi: 10.1677/joe.0.175r001
  18. Atalayer, D. (2013). Anorexia of Aging and Gut Hormones. Aging and Disease, 04(05), 264–275. doi: 10.14336/ad.2013.0400264
  19. Zoico, E., Di Francesco, V., Mazzali, G., Vettor, R., Fantin, F., & Bissoli, L. et al. (2004). Adipocytokines, Fat Distribution, and Insulin Resistance in Elderly Men and Women. The Journals Of Gerontology Series A: Biological Sciences And Medical Sciences, 59(9), M935-M939. doi: 10.1093/gerona/59.9.m935
  20. Ruhl, C., Everhart, J., Ding, J., Goodpaster, B., Kanaya, A., & Simonsick, E. et al. (2004). Serum leptin concentrations and body adipose measures in older black and white adults. The American Journal Of Clinical Nutrition, 80(3), 576–583. doi: 10.1093/ajcn/80.3.576
  21. Roberts, S., Nicholson, M., Staten, M., Dallal, G., Sawaya, A., & Heyman, M. et al. (1997). Relationship Between Circulating Leptin and Energy Expenditure in Adult Men and Women Aged 18 Years to 81 Years. Obesity Research, 5(5), 459–463. doi: 10.1002/j.1550–8528.1997.tb00671.x
  22. Soares, M., Piers, L., O’Dea, K., & Collier, G. (2000). Plasma leptin concentrations, basal metabolic rates and respiratory quotients in young and older adults. International Journal Of Obesity, 24(12), 1592–1599. doi: 10.1038/sj.ijo.0801450
  23. Cohn, S., Vaswani, A., Zanzi, I., Aloia, J., Roginsky, M., & Ellis, K. (1976). Changes in body chemical composition with age measured by total-body neutron activation. Metabolism, 25(1), 85–96. doi: 10.1016/0026–0495(76)90163–3
  24. Forbes, G., & Reina, J. (1970). Adult lean body mass declines with age: Some longitudinal observations. Metabolism, 19(9), 653–663. doi: 10.1016/0026–0495(70)90062–4
  25. B. Rennard, R. Ertl, G. Gossman, R. Robbins, S. RennardChicken soup inhibits neutrophil chemotaxis in vitro Chest, 118 (4) (2000), pp. 1150–1157
  26. S. DavisAn overview of the antifungal properties of allicin and its breakdown products — the possibility of a safe and effective antifungal prophylactic Mycoses, 48 (2) (2005), pp. 95–100
  27. I. Lete, J. AlluέThe effectiveness of ginger in the prevention of nausea and vomiting during pregnancy and chemotherapy Integr Med Insights, 11 (2016)
  28. H. Kruizenga, S. van Keeken, P. Weijs, L. Bastiaanse, S. Beijer, G. Huisman-de Waal, et al.Undernutrition screening survey in 564,063 patients: patients with a positive undernutrition screening score stay in hospital 1.4 d longer Am J Clin Nutr, 103 (4) (2016), pp. 1026–1032
  29. J. Regenstein, M. Chaudry, C. RegensteinThe Kosher and Halal food laws Compr Rev Food Sci Food Saf, 2 (3) (2003), pp. 111–127
  30. Find a Jewish Senior Community — AJAS [Internet]. Ajas.org. 2020[cited 14 February 2020]. Available from: https://ajas.org/senior-living/find-a-jewish-senior-community/

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Adam Plotkin

Adam Plotkin

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Post-Baccalaureate research assistant in the Molecular and Clinical Nutrition Lab at the National Institutes of Health